Firm foundations

Building firm foundations for therapy development.

The phase I trial in the oncology treatment development paradigm is supremely challenged on the one hand by being required to identify a satisfactory dose/regimen that will be carried forward in pilot and definitive efficacy evaluations and on the other hand to minimize patient's exposure to ineffective doses. The result of this compromise is often scant data on which to base the entire subsequ...

Complexity and Management: Moving From Fad To Firm Foundations

CEOs have many different complexity approaches to choose from. The books reviewed in this Special Issue more or less define frequently obscure complexity science terms and complexity science theories have been given meanings more relevant to firms. Organization change methods leading toward emergence and empowerment are powerfully set forth. But in the founding issue of Emergence one of us (McK...

Strategy, Bargaining, and Economic Organization: Some Thoughts on the Transaction Cost Foundations of Firm Strategy

Molecular systematics of red algae: building future structures on firm foundations

Red algal systematics has a solid morphological foundation, based on analyses of female reproductive structures and post-fertilization development by Kylin and other workers. Recognition of the value of pit-plug ultrastructure was a catalyst leading to refinement of the Kylinian ordinal classification. Molecular approaches to systematics have further advanced our understanding of the red algae ...

Exploitation of the Self in Community-based Software Production - Workers’ Freedoms or Firm Foundations